Etohcta3^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Etohcta3^DBA/2J
• Name: ethanol conditioned taste aversion 3; DBA/2J
• MGI ID: MGI:2155409
• QTL: Etohcta3 Location: unknown Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50271

841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta3 (P<0.01 at D3Mc1) and Etohcta4 (P<0.01 at Gnat2) mapped to Chromosome 3 at 21 cM and 49 cM, respectively. Etohcta3 and Etohcta4 are associated with ethanol-induced taste aversion at low-dose ethanol injection following the paired taste. Candidate genes on Chromosome 3 include acetylcholine receptor subunits. Taste3(P<0.01 at D3Byu4) mapped to 40.6 cM on Chromosome 3 and is associated with saccharin preference.

References

• Original: J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• All: 1 reference(s)