Myo7a^26SB
Chemically induced Allele Detail

Summary

• Symbol: Myo7a^26SB
• Name: myosin VIIA; shaker 26SB
• MGI ID: MGI:2155417
• Synonyms: 26SB, Myo7a^sh1-1R, sh1^26SB, sh1^OR-26SB
• Gene: Myo7a Location: Chr7:97700267-97768731 bp, - strand Genetic Position: Chr7, 53.57 cM
• Alliance: Myo7a^26SB page

Mutation origin

• Strain of Origin: BALB/cRl

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-A transversion mutation is predicted to result in a phenylalanine to isoleucine change at position 1800 in the encoded protein. This mutation is predicted to lie within the tail domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that 46% of the normal level of the protein was expressed in testis and 18% of the normal level in kidney. (J:49926)
• Inheritance: Recessive

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Myo7a Mutation: 118 strains or lines available

References

• Original: J:10283 Rinchik EM, et al., A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci U S A. 1990 Feb;87(3):896-900
• All: 6 reference(s)