Myo7a^3336SB
Chemically induced Allele Detail

Summary

• Symbol: Myo7a^3336SB
• Name: myosin VIIA; shaker 3336SB
• MGI ID: MGI:2155420
• Synonyms: Myo7a^sh1-3R, sh1^3336SB, sh1^OR-3336SB
• Gene: Myo7a Location: Chr7:97700267-97768731 bp, - strand Genetic Position: Chr7, 53.57 cM
• Alliance: Myo7a^3336SB page

Mutation origin

• Strain of Origin: BALB/cRl

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-A transversion mutation is predicted to result in a cysteine to stop codon change at position 2182 in the encoded protein. This mutation is predicted to lie within the tail domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that approximately 13% of the normal level of the protein was expressed. (J:49926)
• Inheritance: Recessive

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Myo7a Mutation: 118 strains or lines available

References

• Original: J:73419 Rinchik EM, et al., Reverse genetics in the mouse and its application to the study of deafness. Ann N Y Acad Sci. 1991;630:80-92
• All: 5 reference(s)