Myo7a^4494SB
Chemically induced Allele Detail

Summary

• Symbol: Myo7a^4494SB
• Name: myosin VIIA; shaker 4494SB
• MGI ID: MGI:2155421
• Synonyms: Myo7a^sh1-4R, sh1^4494SB, sh1^OR-4494SB
• Gene: Myo7a Location: Chr7:97700267-97768731 bp, - strand Genetic Position: Chr7, 53.57 cM
• Alliance: Myo7a^4494SB page

Mutation origin

• Strain of Origin: BALB/cRl

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Inversion
• Mutation details: A small 6 nt inversion and substitution of two T nucleotides with a single A resulted in a frameshift and introduction of a stop codon 5 amino acids downstream in the encoded protein. This mutation is predicted to lie in the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that less than 1% of the normal level of the protein was expressed. (J:49926)
• Inheritance: Recessive

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Myo7a Mutation: 118 strains or lines available

References

• Original: J:73419 Rinchik EM, et al., Reverse genetics in the mouse and its application to the study of deafness. Ann N Y Acad Sci. 1991;630:80-92
• All: 6 reference(s)