Eae10^SJL/J
QTL Variant Detail

Summary

• QTL variant: Eae10^SJL/J
• Name: experimental allergic encephalomyelitis susceptibility 10; SJL/J
• MGI ID: MGI:2155435
• QTL: Eae10 Location: Chr3:131736617-148451178 bp Genetic Position: Chr3, cM position of peak correlated region/allele: 67.53 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SJL/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers earlier onset of EAE compared to B10.S/DvTe. (J:49054)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49054

Authors isolated quantitative trait loci believed to be invloved with the disease frequency of experimental allergic encephalomyelitis (EAE). (SJL/J x B10.S/DvTe)F2; SJL/J (susceptible) and B10.S/DvTe (resistant) mice; were bred to create F2 progeny used in the analysis.

A genome wide scan of 291 affected and 390 unaffected animals indicated the presence a locus mapping to mouse Chromosome 3, between D3Mit14 and D3Mit147, named Eae10 by the authors.

References

• Original: J:49054 Butterfield RJ, et al., New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. J Immunol. 1998 Aug 15;161(4):1860-7
• All: 1 reference(s)