Sos1^tm1Dlb
Targeted Allele Detail

Summary

• Symbol: Sos1^tm1Dlb
• Name: SOS Ras/Rac guanine nucleotide exchange factor 1; targeted mutation 1, David DL Botwell
• MGI ID: MGI:2155441
• Gene: Sos1 Location: Chr17:80701181-80787882 bp, - strand Genetic Position: Chr17, 50.67 cM, cytoband C3-D
• Alliance: Sos1^tm1Dlb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38321
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ-neomycin gene fusion was inserted in frame into coding sequence of the gene. A fusion protein is expressed from this allele that consists of the first 44 amino acids of the protein fused to beta-galactosidase. (J:38321)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sos1 Mutation: 69 strains or lines available

References

• Original: J:38321 Wang DZ, et al., Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development. Genes Dev. 1997 Feb 1;11(3):309-20
• All: 1 reference(s)