Sos1^tm1Lowy
Targeted Allele Detail

Summary

• Symbol: Sos1^tm1Lowy
• Name: SOS Ras/Rac guanine nucleotide exchange factor 1; targeted mutation 1, Douglas R Lowy
• MGI ID: MGI:2155442
• Gene: Sos1 Location: Chr17:80701181-80787882 bp, - strand Genetic Position: Chr17, 50.67 cM, cytoband C3-D
• Alliance: Sos1^tm1Lowy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60649
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced an exon encoding the highly conserved N-terminal catalytic domain of the protein. (J:60649)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sos1 Mutation: 69 strains or lines available

References

• Original: J:60649 Qian X, et al., The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties. EMBO J. 2000 Feb 15;19(4):642-54
• All: 1 reference(s)