Tmevd2^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tmevd2^DBA/2J
• Name: Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2; DBA/2J
• MGI ID: MGI:2155448
• QTL: Tmevd2 Location: Chr3:92463302-92463549 bp Genetic Position: Chr3, cM position of peak correlated region/allele: 40.14 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

This is a susceptibility allele (J:43978). Theiler's murine encephalomyelitis virus (TMEV), introduced into the central nervous system (CNS), causes CNS demyelination. The H2-D1 region and at least two non-H2 loci are involved: Tmevd1 on Chr 6, and this second locus, Tmevd2, which has been localized on Chr 3 using the susceptible DBA/2 and resistant C57BL/6 strains and the BXD recombinant inbred strain panel (J:10200).

Mapping and Phenotype information for this QTL, its variants and associated markers

J:43978

The segregation of genes that may contribute to the susceptibility of Theilers murine encephalomyelitis in mice were analyzed in (BALB/cByJ x DBA/2J)F1 x BALB/cByJ and DBA/2J backcross progeny using microsatellites from Chromosomes 3, 6 and 17. Significant association of Tmevd2 with mouse Chromosome 3 marker D3Mit156 was observed. The authors indicated that Tmevd2 mapped 1.1 cM proximal of D3Mit101. The authors hypothesize that Tmevd2 and mouse Eae3 may in fact be the same locus.

References

• Original: J:43978 Teuscher C, et al., Evidence that Tmevd2 and eae3 may represent either a common locus or members of a gene complex controlling susceptibility to immunologically mediated demyelination in mice. J Immunol. 1997 Nov 15;159(10):4930-4
• All: 1 reference(s)