Letohc1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Letohc1^C57BL/6J
• Name: low ethanol consumption 1; C57BL/6J
• MGI ID: MGI:2155464
• QTL: Letohc1 Location: Chr3:143352986-143353183 bp Genetic Position: Chr3, cM position of peak correlated region/allele: 67.53 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:40854

Ethanol consumption in mice was analyzed in selectively breed mice derived from an F2 population of intercrossed (C57BL/6J x DBA/2J)F1 mice. Whereas C57BL/6J are high consumers of alcohol and DBA/2J are low consumers. The concentration of ethanol used was 10%. With low preference mice and high preference mice mated for a maximum of 4 generations. In generation 4 of the Low selected line a significant QTL was observed and associated with D3Mit17. Authors suggest Adh1 may be a candidate gene.

References

• Original: J:40854 Belknap JK, et al., Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice. Behav Genet. 1997 Jan;27(1):55-66
• All: 1 reference(s)