Eae42^SJL/J
QTL Variant Detail

Summary

• QTL variant: Eae42^SJL/J
• Name: experimental allergic encephalomyelitis susceptibility 42; SJL/J
• MGI ID: MGI:2155482
• QTL: Eae42 Location: unknown Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: SJL/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers EAE susceptibility compared to C57BL/10SnSg. (J:34892)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:34892

In order to localize quantitative trait loci (QTLs) affecting the experimental autoimmune encephalomyelitis (EAE) phenotype, 68 susceptible and 68 immune mice derived from a (B10.S x SJL/J)F1 x B10.S backcross were analyzed. The SJL/J strain is highly susceptible to EAE while B10.S is resistant. QTL Eae3 (p = 0.001) was localized on mouse Chromosome 3 linked to D3Mit244.

6.30.2015 Curator Note: Because Eae3 was originally mapped in J:26734 in 1995 using the F2 progeny from a B10.RIII x RIIIS/J cross, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Eae42.

References

• Original: J:34892 Encinas JA, et al., Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J Immunol. 1996 Sep 1;157(5):2186-92
• All: 1 reference(s)