Smad1^tm2Rob
Targeted Allele Detail

Summary

• Symbol: Smad1^tm2Rob
• Name: SMAD family member 1; targeted mutation 2, Elizabeth J Robertson
• MGI ID: MGI:2155484
• Synonyms: Smad1^flox, Smad1^RobPC
• Gene: Smad1 Location: Chr8:80065024-80126057 bp, - strand Genetic Position: Chr8, 37.56 cM
• Alliance: Smad1^tm2Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71998
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An homologous recombination event inserted an EcoRI and loxP site 2kb 5' of the first coding exon, and a loxP-flanked hygromycin resistance cassette 1.7kb 3' of this exon. (J:71998)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad1^tm2Rob

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smad1 Mutation: 32 strains or lines available

References

• Original: J:71998 Tremblay KD, et al., Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development. 2001 Sep;128(18):3609-21
• All: 22 reference(s)