Rapop3^BALB/cHeA
QTL Variant Detail

Summary

• QTL variant: Rapop3^BALB/cHeA
• Name: radiation-induced apoptosis 3; BALB/cHeA
• MGI ID: MGI:2155516
• QTL: Rapop3 Location: Chr3:90511217-100464137 bp Genetic Position: Chr3, cM position of peak correlated region/allele: 34.38 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/cHeA

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to radiation-induced apoptosis in thymocytes compared to STS/A. (J:30582)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:30582

Susceptibility to cell death (apoptosis) varies significantly between the inbred strains BALB/cHeA (resistant) and STS/A (susceptible), therefore recombinant congenic strains derived from these inbreds will be informative for identifying chromosome regions contributing to the cell death phenotype. In F2 crosses involving recombinant congenic strain CcS-8 with progenitor inbred BALB/cHeA and CcS-8 with CcS-10 a highly significant association was found in the region of mouse Chromosome 3 including the D3Mit28 and D3Mit11 markers. The symbol assigned for the phenotype is Rapop3 and can be considered a quantitative trait.

References

• Original: J:30582 Mori N, et al., Apoptosis susceptibility genes on mouse chromosome 9 (Rapop2) and chromosome 3 (Rapop3). Genomics. 1995 Dec 10;30(3):553-7
• All: 1 reference(s)