Aod2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Aod2^C57BL/6J
• Name: autoimmune ovarian dysgenesis 2; C57BL/6J
• MGI ID: MGI:2155557
• QTL: Aod2 Location: Chr3:37179742-68716946 bp Genetic Position: Chr3, cM position of peak correlated region/allele: 18.3 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:31314

Thymectomized progeny, from a backcross of (C57BL/6J x A/J)F1 (susceptible to autoimmune ovarian dysgenesis - AOD) and C57BL/6J (resistant) mice, which exhibited autoimmune oophoritis and ovarian atrophy were subjected to linkage analysis. Using 131 microsatellite loci covering the genome, maximal linkage (P = 0.0007) of a quantitative trait locus associated with phentypic expression of atrophy was found on mouse Chromosome 3 in association with markers D3Mit224, D3Mit63, D3Mit133, D3Mit226, D3Mit182, D3Mit227, D3Mit64, D3Mit5, D3Mit6 and D3Mit65. The authors designated this locus Aod2. Maximum likelihood estimates were carried out on Chromosome 3 by multilocus linkage analysis. A 95% confidence interval was found to be bordered by D3Mit21 (Il2) and D3Mit154. The authors note the presence of Il2, Fgf2, and in particular Idd3 within this region.

References

• Original: J:31314 Teuscher C, et al., Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3. J Exp Med. 1996 Feb 1;183(2):631-7
• All: 2 reference(s)