Bglq3^LG/J
QTL Variant Detail

Summary

• QTL variant: Bglq3^LG/J
• Name: body growth late QTL 3; LG/J
• MGI ID: MGI:2155559
• QTL: Bglq3 Location: unknown Genetic Position: Chr3, cM position of peak correlated region/allele: 76.22 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: LG/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 3, Hps3 (12.5 cM) showed differential expression between A/a and A/A^vy animals on the unrestricted diet. Diabesity QTL Insq3 (2.6 cM) maps near this candidate gene.Candidate genes for diabesity QTLs Bglq3 (49 cM) and Wt10q2 (61 cM) are Fabp2 (55 cM) and Ampd2 (50.4 cM). Fabp2 shows differential expression between the restricted and unrestricted diets on the A/a background and Ampd2 shows differential expression between the restricted and unrestricted diets on the A/A^vy background.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:32208

Quantitative trait loci (QTLs) effecting age specific body growth rates in mice were mapped using 535 F2 intercross mice from a (LG/J x SM/J)F1 cross. LG/J mice exhibit a large size at 60 days of age whereas SM/J exhibit a Small size. QTLs on 16 of 19 autosomes effective age specific growth was detected in a genome wide scan using microsatellite markers. QTL marker Bglq3 was associated with late growth rate and mapped to mouse Chromosome 3 near D3Mit32.

References

• Original: J:32208 Cheverud JM, et al., Quantitative trait loci for murine growth. Genetics. 1996 Apr;142(4):1305-19
• All: 1 reference(s)