Chrna3^tm1Bay
Targeted Allele Detail

Summary

• Symbol: Chrna3^tm1Bay
• Name: cholinergic receptor, nicotinic, alpha polypeptide 3; targeted mutation 1, Baylor College of Medicine
• MGI ID: MGI:2155602
• Synonyms: alpha3 -
• Gene: Chrna3 Location: Chr9:54917401-54933846 bp, - strand Genetic Position: Chr9, 29.84 cM
• Alliance: Chrna3^tm1Bay page

Phenotypic findings of Chrna3^tm1Bay/Chrna3^tm1Bay mice.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54994
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.8kb genomic fragment containing exon 3 was replaced by an HPRT minigene. These sequences encode three of the four transmembrane domains, the amphipathic helix domain and the four cysteines essential for ligand binding. No transcript produced from this allele was detectable by northern blotting. (J:54994)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrna3 Mutation: 35 strains or lines available

References

• Original: J:54994 Xu W, et al., Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5746-51
• All: 11 reference(s)