Alan2^B10.O20/Dem
QTL Variant Detail

Summary

• QTL variant: Alan2^B10.O20/Dem
• Name: alloantigen response 2; B10.O20/Dem
• MGI ID: MGI:2155721
• QTL: Alan2 Location: unknown Genetic Position: Chr4, cM position of peak correlated region/allele: 62.53 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: B10.O20/Dem

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased alloantigen response compared to O20/A. (J:67657)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:67657

Mapping was performed on a (OcB-9 x O20/A)F2 intercross to identify loci affecting the intensity of the mixed lymphocyte response (MLR). OcB-9 is a recombinant congenic strain derived from progenitor strains O20/A (87.5% of genome) and B20.O20 (12.5% of genome). A locus designated Alan2 (alloantigenic response 2) mapped to mouse Chromosome 4 from 59.5 cM - 71.0 cM with highest association for response to alloantigens tested at D4Mit72 (P = 0.000434 for B10 alloantigens, P = 0.000119 for BALB/c alloantigens). Colony stimulating factor 3 receptor (Csf3r) colocalizes with Alan2 and may be a possible candidate gene.

References

• Original: J:67657 Havelkova H, et al., A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBA. Genes Immun. 2000 Dec;1(8):483-7
• All: 1 reference(s)