Bpq3^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bpq3^C57BL/6J
• Name: blood pressure QTL 3; C57BL/6J
• MGI ID: MGI:2155724
• QTL: Bpq3 Location: Chr4:59402240-59402381 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 32.54 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to salt-induced hypertension compared to A/J. (J:66987)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66987

C57BL/6J are sensitive to salt induced hypertension whereas A/J are non-salt-sensitive allowing for a genome wide scan for loci contributing to hypertension. 250 male mice from reciprocal backcrosses between (C57BL/6J x A/J)F1 x C57BL/6J were informativein mapping 6 Blood pressure QTLs to 5 mouse chromosomes. Bpq3 had a main effect and mapped with markers on mouse Chromosome 4. Bpq3 mapped with D4Mit164 with an F value of 56 and a P value of 1.3 x 10e-12. A suggested candidate for Bpq3 was Npr2.

References

• Original: J:66987 Sugiyama F, et al., Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001 Jan 1;71(1):70-7
• All: 1 reference(s)