Asm2^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Asm2^MRL/MpJ
• Name: autoimmune sialadenitis in MRL mice 2; MRL/MpJ
• MGI ID: MGI:2155726
• QTL: Asm2 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers sialadenitis susceptibility in female animals compared to C3H/HeJ. (J:66459)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Asm2 interacts additively with Asm1 and a locus at D18Mit227.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66459

175 MRL/MpJ-Tnfrsf6^lpr/Tnfrsf6^lpr x (MRL/MpJ-Tnfrsf6^lpr/Tnfrsf6^lpr X C3H/HeJ-Tnfrsf6^lpr/Tnfrsf6^lpr)F1 backcross animals were typed for 139 microsatellite markers at an average spacing of 10 cM (excluding sex chromosomes) to identify QTLs associated with susceptibility to autoimmune sialadenitis.Parental strain MRL/MpJ-Tnfrsf6^lpr/Tnfrsf6^lpr is highly susceptible to sialadenitis (93.3% incidence) compared to parental strain C3H/HeJ-Tnfrsf6^lpr/Tnfrsf6^lpr (4% incidence). A highly significant locus, Asm1 (autoimmune sialadenitis in MRL mice 1), maps to mouse Chromosome 10 from38.4 cM - 40.0 cM (LOD = 4.8 at D10Mit115 and D10Mit259). Suggestive loci mapped to mouse Chromosome 18 at 22 cM (LOD = 3.7 at D18Mit227) and mouse Chromosome 1 at 65cM (LOD = 2.9 at D1Mit494). Asm1, D18Mit227, and D1Mit494 appear to interact in an additive fashion. Asm1 maps near another autoimmune QTL, Lmb4. A female-specific locus, Asm2, mapped to mouse Chromosome 4 from 48.5 cM - 53.6 cM (LOD = 4 at D4Mit255 and D4Mit199).

References

• Original: J:66459 Nishihara M, et al., Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: additive and hierarchical properties of polygenic inheritance. Arthritis Rheum. 1999 Dec;42(12):2616-23
• All: 1 reference(s)