Afpq11^DU6i
QTL Variant Detail

Summary

• QTL variant: Afpq11^DU6i
• Name: abdominal fat percent QTL 11; DU6i
• MGI ID: MGI:2155737
• QTL: Afpq11 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: DU6i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased abdominal fat percentages compared to DBA/2. (J:66233)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Afpq11 exhibits an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66233

QTLs effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i x DBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan.

Locations of the QTLs were provided by the authors and may not be equivalent to the closest microsatellites. Liverweight QTL 1, body weight QTL 7, insulin QTL 1 abdominal fat weight QTL 2 and abdominal fat percent QTL 2 were mapped to mouse Chromosome 4 to positions 59, 61, 66, 66, and 66 respectively.

10.03.2014 - Curator Note: We had originally associated the abdominal fat weight QTL 2 identified here, mapping to 66cM on mouse Chr 4, as Afw2. Afw2 was originally mapped using a different cross, an outbred cross of DU6 x DUK, in J:49578 in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Afw14.

01.07.2015 - Curator Note: We had originally associated the body weight QTL 7 identified here, mapping to 61cM on Chr4 as Bw7. Bw7 was originally mapped using a different cross, an outbred cross of DU6 x DUK,in J:49578, in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Bw37.

04.14.2015 - Curator Note: Because the abdominal fat percent QTL 2, (Afpq2) was orginally mapped in J:49578 in 1998 using an an outbred cross of DU6 x DUK, which differs from the cross used here we consider the current mapping study a separate mapping experiment and have named the QTL Afpq11.

10.06.2015 - Curator Note : Because Lwq1 (liver weight QTL 1) was originally mapped in J:49578 in 1998 using an outbred cross of DU6 x DUK, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Lwq10.

References

• Original: J:66233 Brockmann GA, et al., Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res. 2000 Dec;10(12):1941-57
• All: 1 reference(s)