Gjb3^tm1Kwi
Targeted Allele Detail

Summary

• Symbol: Gjb3^tm1Kwi
• Name: gap junction protein, beta 3; targeted mutation 1, Klaus Willecke
• MGI ID: MGI:2155738
• Synonyms: connexin31-
• Gene: Gjb3 Location: Chr4:127219028-127224633 bp, - strand Genetic Position: Chr4, 61.48 cM
• Alliance: Gjb3^tm1Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68014
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A promoterless lacZ gene without a nuclear localization signal and neomycin resistance cassette were inserted immediately downstream of the start codon. Beta-galactosidase is expressed from this allele in a pattern similar to the endogenous gene. (J:68014)

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gjb3 Mutation: 97 strains or lines available

References

• Original: J:68014 Plum A, et al., Connexin31-deficiency in mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation. Dev Biol. 2001 Mar 15;231(2):334-47
• All: 4 reference(s)