Gjb2^tm1Kwi
Targeted Allele Detail

Summary

• Symbol: Gjb2^tm1Kwi
• Name: gap junction protein, beta 2; targeted mutation 1, Klaus Willecke
• MGI ID: MGI:2155739
• Gene: Gjb2 Location: Chr14:57336059-57342159 bp, - strand Genetic Position: Chr14, 30.1 cM, cytoband D1-E1
• Alliance: Gjb2^tm1Kwi page

Small size of Gjb2^tm1Kwi/Gjb2^tm1Kwi embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46665
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1065 bp genomic fragment within exon 2, corresponding to amino acids 83-226, was replaced with a neomycin resistance cassette. (J:46665)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gjb2 Mutation: 22 strains or lines available

References

• Original: J:46665 Gabriel HD, et al., Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice. J Cell Biol. 1998 Mar 23;140(6):1453-61
• All: 1 reference(s)