Triglq1^SM/J
QTL Variant Detail

Summary

• QTL variant: Triglq1^SM/J
• Name: triglyceride QTL 1; SM/J
• MGI ID: MGI:2155750
• QTL: Triglq1 Location: Chr4:25683240-25683429 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 10.61 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased plasma triglyceride levels in female animals compared to A/J. (J:64138)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Candidate Genes

J:99477

Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes.

Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:64138

The SMXA (SM/J x A/J) RI line was informative in mapping suggestive QTLs for Body Weight, Insulin, Triglyceride and Phospholipid in selected RI Strians. In female mice a QTL (Trigq1) influencing Triglyceride levels in blood mapped to mouse Chromosome 4 and was associated with D4Mit2.

References

• Original: J:64138 Anunciado RV, et al., Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis. Exp Anim. 2000 Jul;49(3):217-24
• All: 1 reference(s)