Ascl2^tm1.1Nagy
Targeted Allele Detail

Summary

• Symbol: Ascl2^tm1.1Nagy
• Name: achaete-scute family bHLH transcription factor 2; targeted mutation 1.1, Andras Nagy
• MGI ID: MGI:2155757
• Synonyms: Ascl2-lacZ, Mash2-lacZ
• Gene: Ascl2 Location: Chr7:142520566-142523001 bp, - strand Genetic Position: Chr7, 88.08 cM
• Alliance: Ascl2^tm1.1Nagy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57828
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: This allele is a derivative of Ascl2^tm1Nagy in which the loxP flanked neomycin resistance cassette was removed in the germ line via Cre mediated recombination by crossing Ascl2^tm1Nagy mice with transgenic mice expressing Cre under the control of the CMV promoter. This allele expressed beta-galactosidase under the control of the endogenous gene promoter. (J:57828)

Expression

In Mice Carrying this Mutation:

35 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ascl2 Mutation: 15 strains or lines available

References

• Original: J:57828 Tanaka M, et al., Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation. Mech Dev. 1999 Sep;87(1-2):129-42
• All: 4 reference(s)