Remslp1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Remslp1^C57BL/6J
• Name: rapid eye movement sleep 1; C57BL/6J
• MGI ID: MGI:2155758
• QTL: Remslp1 Location: unknown Genetic Position: Chr4, cM position of peak correlated region/allele: 31.66 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:61416

13 CXB RI strains were used in mapping QTLs affecting rapid eye movement sleep (REMS) and slow-wave sleep (SWS). 233 loci were screened in 214 adult male mice using sleeping pattern data recorded over a period of 2 days. The C57BL/6J parental strain spends more time in REM sleep (49.3 1.3) and slow-wave sleep (7.4 0.4) during the light phase compared to BALB/cByJ (REMS=45.0 1.6; SWS = 4.9 0.4), with the C57BL/6J phenotype appearing to be dominant. CXB RI strains have a SWS distribution pattern intermediate of the two parental strains, and a trimodal REMS distribution pattern corresponding to the 2 parental modes and intermediate mode. 6 suggestive QTLs were mapped in this study. Remslp1 (linked to D4Mit288, Mup1, and D4Mit14 on Chromosome 4 at 28cM), Remslp2 (linked to Tcp1 on Chromosome 16 at 7.5 cM), and Remslp3 (linked to D16Mit47 on Chromosome 16 at 43 cM) are loci associated with 24-hour REMS and dark phase REMS. Remslp4 (linked to Tcp1 and D17Mit47 on Chromosome 17 at 10 cM) and Remslp5 (linked to Glo2 on Chromosome 17 at 11 cM) are loci associated with 24-hr REMS and light phase REMS.

References

• Original: J:61416 Toth LA, et al., A quantitative genetic analysis of slow-wave sleep and rapid-eye movement sleep in CXB recombinant inbred mice. Behav Genet. 1999 Sep;29(5):329-37
• All: 1 reference(s)