Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:31797PCR analysis using microsatellite DNA polymorphic markers was preformed in (C57BL/6J x RF/J)F1 animals. Allelic losses were detected in 21/47 gamma-radiation induced thymic lymphomas. Analysis of markers located on six other chromosomes as well as on the proximal region of mouse Chromosome 4 indicated the existance of a tumor suppressor gene region (Tlsr1) on mouse Chromosome 4 of about 0.6 cM between the makers D4Wsm1 and D4Mit9. Additionally, a more distal tumor suppressor gene region (Tlsr2) was found centered at D4Mit54. From these data the following order of loci was determined on mouse Chromosome 4: D4Mit50, D4Mit17, D4Wsm1, Tlsr1, D4Mit9, D4Mit205, D4Mit12, Tlsr2, D4Mit54, D4Mit13. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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