Sprol1^BALB/cHeA
QTL Variant Detail

Summary

• QTL variant: Sprol1^BALB/cHeA
• Name: spontaneous proliferation 1; BALB/cHeA
• MGI ID: MGI:2155781
• QTL: Sprol1 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: BALB/cHeA

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased lymphocyte proliferation compared to STS/A.
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:56029

Lymphocytes of mouse strains BALB/cHeA and STS/A differ in their response to the CD3 antibody. BALB/c lymphocytes are intermediate reponders while STS lymphocytes do not respond to this stimulus. The authors used recombinant congenic strains of the BALB/c - c-STS/Dem (CcS/Dem) series to examine the genetic basis of proliferative response to anti-CD3. The authors observed proliferation in complete RPMI medium without anti-CD3. This was controlled by the locus Sporl1 (spontaneous proliferation) which mapped to markers D4Mit23 and D4Mit7 (corrected P = 0.0046 and 0.0598 respectively). STS allele controls higher response. This response does not depend upon age or gender. Putative candidate genes in this region include Tlr4, Tal2, Lapls3-22 and Lapls1-10.

References

• Original: J:56029 Havelkova H, et al., T-cell proliferative response is controlled by loci Tria4 and Tria5 on mouse chromosomes 7 and 9. Mamm Genome. 1999 Jul;10(7):670-4
• All: 1 reference(s)