Cms1^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Cms1^DBA/2J
• Name: resistance to Coccidioides immitis 1; DBA/2J
• MGI ID: MGI:2155782
• QTL: Cms1 Location: Chr4:62427406-62438155 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to Coccidioides immitis infection compared to C57BL/6J. (J:55132)
• Inheritance: Not Specified

Notes

Cms1^C57BL/6J/Cms1^DBA/2J heterozygotes are resistant. It is not known whether intermediate susceptibility is due to a third allele of Cms1 or to modifying genes. Males are more susceptible than females, although Cms1 is not X-linked. Resistance is radiosensitive, indicating that it depends on a dividing cell. Cms1 appears to be active in spleen cells, since resistance can be transferred to irradiated susceptible hosts by injection of spleen cells from resistant donors (J:7871).

Mapping and Phenotype information for this QTL, its variants and associated markers

J:55132

DBA/2J mice are more resistant to Coccidioides immitis infection then are C57BL/6J mice allowing for the genetic mapping of genes that determine resistance. The BXD RI line was informative to map genes to mouse Chromosomes 4 and 6. One gene was designated as Cms1 and showed a significant association with mouse Chromosome 4 marker Alad the other gene Cms2 was associated with Tnfrsf1a on mouse Chromosome 6. Moreover (DBA/2J x C57BL/6J) F1 x C57BL/6J backcross progeny that carried the DBA/2J allele at either Tnfrsf1a or Alad exhibited a higher resistant phenotype then mice that carried the C57BL/6J allele.

References

• Original: J:55132 Fierer J, et al., Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice. Infect Immun. 1999 Jun;67(6):2916-9
• All: 1 reference(s)