Summary |
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Variant origin |
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Variant description |
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Notes |
Cms1C57BL/6J/Cms1DBA/2J heterozygotes are resistant. It is not known whether intermediate susceptibility is due to a third allele of Cms1 or to modifying genes. Males are more susceptible than females, although Cms1 is not X-linked (J:7871).
Mapping and Phenotype information for this QTL, its variants and associated markersJ:55132DBA/2J mice are more resistant to Coccidioides immitis infection then are C57BL/6J mice allowing for the genetic mapping of genes that determine resistance. The BXD RI line was informative to map genes to mouse Chromosomes 4 and 6. One gene was designated as Cms1 and showed a significant association with mouse Chromosome 4 marker Alad the other gene Cms2 was associated with Tnfrsf1a on mouse Chromosome 6. Moreover (DBA/2J x C57BL/6J) F1 x C57BL/6J backcross progeny that carried the DBA/2J allele at either Tnfrsf1a or Alad exhibited a higher resistant phenotype then mice that carried the C57BL/6J allele. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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