About   Help   FAQ
Cms1C57BL/6J
QTL Variant Detail
Summary
QTL variant: Cms1C57BL/6J
Name: resistance to Coccidioides immitis 1; C57BL/6J
MGI ID: MGI:2155783
QTL: Cms1  Location: Chr4:62427406-62438155 bp  Genetic Position: Chr4, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to Coccidioides immitis infection compared to DBA/2J.
Inheritance:    Not Specified
Notes
Cms1C57BL/6J/Cms1DBA/2J heterozygotes are resistant. It is not known whether intermediate susceptibility is due to a third allele of Cms1 or to modifying genes. Males are more susceptible than females, although Cms1 is not X-linked (J:7871).

Mapping and Phenotype information for this QTL, its variants and associated markers

J:55132

DBA/2J mice are more resistant to Coccidioides immitis infection then are C57BL/6J mice allowing for the genetic mapping of genes that determine resistance. The BXD RI line was informative to map genes to mouse Chromosomes 4 and 6. One gene was designated as Cms1 and showed a significant association with mouse Chromosome 4 marker Alad the other gene Cms2 was associated with Tnfrsf1a on mouse Chromosome 6. Moreover (DBA/2J x C57BL/6J) F1 x C57BL/6J backcross progeny that carried the DBA/2J allele at either Tnfrsf1a or Alad exhibited a higher resistant phenotype then mice that carried the C57BL/6J allele.

References
Original:  J:55132 Fierer J, et al., Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice. Infect Immun. 1999 Jun;67(6):2916-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory