Summary |
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Variant origin |
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Variant description |
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Phenotypes |
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View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Gasa1 exhibits a gene dosage (additive) effect.
Candidate Genes
Previous study with thymectomized (BALB/cCrSlc x C57BL/6)F2 animals mapped susceptibility to autoimmune gastritis to mouse Chromosome 4 (Gasa1, Gasa2), Chromosome 6 (Gasa3), and Chromosome 17 (Gasa4). Three of these loci map near other autoimmune QTLs. Mapping and Phenotype information for this QTL, its variants and associated markersJ:54699To determine the mode of inheritance and to map the genes causing susceptibility to autoimmune gastritis in mice, F1 and F2 populations were produced using the BALB/cCrSlc (susceptible) and C57BL/6 (resistant) strains. Two regions with linkage to experimental autoimmune gastritis (EAG) were identified on distal Chromosome 4 and were designated Gasa1 and Gasa2. The mapping data placed Gasa1 in a 10:1 confidence interval from D4Mit308 through to D4Mit343 with highest linkage at D4Mit148 (LRS = 18.9, LOD = 4.39). The BALB/c allele affects the disease in an additive fashion with homozygosity conferring maximum susceptibility to autoimmune gastritis. Putative candidates in this genetic interval include the Lck, C1qa, C1qb and C1qc genes. A second linkage peakcorresponding to Gasa2 was detected on Chromosome 4, centered on D4Mit127 (LRS = 18.8, LOD = 3.9). The BALB/c allele affects the disease in an additive fashion with homozygosity conferring maximum susceptibility to autoimmune gastritis. Putative candidategenes in this region include the Tnfrsf1b, Tnfrsf8, Txgp1 and Tnfrsf9 genes. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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