Gasa2^BALB/cCrSlc
QTL Variant Detail

Summary

• QTL variant: Gasa2^BALB/cCrSlc
• Name: gastritis type A susceptibility locus 2; BALB/cCrSlc
• MGI ID: MGI:2155786
• QTL: Gasa2 Location: Chr4:150010494-150010656 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 80.52 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/cCrSlc

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to autoimmune gastritis compared to C57BL/6. (J:54699)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Gasa2 exhibits a gene dosage (additive) effect.

Heterozygosity at Gasa4 and homozygosity at Gasa2 for BALB/cCrSlc-derived alleles confers maximum increase in disease penetrance.

Candidate Genes

J:97908

Previous study with thymectomized (BALB/cCrSlc x C57BL/6)F2 animals mapped susceptibility to autoimmune gastritis to mouse Chromosome 4 (Gasa1, Gasa2), Chromosome 6 (Gasa3), and Chromosome 17 (Gasa4). Three of these loci map near other autoimmune QTLs.

On mouse Chromosome 4, Gasa1 at 72.5 cM maps near diabetes QTL Idd11 at 64.6 cM. Gasa2 at 77.5 cM maps near diabetes QTL Idd9. Gasa2 was found to interact epistatically with an oophoritis susceptibility QTL on mouse Chromosome 1 named Aod3 (63 cM), and also with Gasa4 on chromosome 17 near the H2 locus. Tnfrsf18 is a potential candidate genes mapping near Gasa2.

Gasa4 maps near an H2-linked locus on mouse Chromosome 17 associated with diabetes susceptibility in NOD x C3H animals.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:54699

To determine the mode of inheritance and to map the genes causing susceptibility to autoimmune gastritis in mice, F1 and F2 populations were produced using the BALB/cCrSlc (susceptible) and C57BL/6 (resistant) strains. Two regions with linkage to experimental autoimmune gastritis (EAG) were identified on distal Chromosome 4 and were designated Gasa1 and Gasa2. The mapping data placed Gasa1 in a 10:1 confidence interval from D4Mit308 through to D4Mit343 with highest linkage at D4Mit148 (LRS = 18.9, LOD = 4.39). The BALB/c allele affects the disease in an additive fashion with homozygosity conferring maximum susceptibility to autoimmune gastritis. Putative candidates in this genetic interval include the Lck, C1qa, C1qb and C1qc genes. A second linkage peakcorresponding to Gasa2 was detected on Chromosome 4, centered on D4Mit127 (LRS = 18.8, LOD = 3.9). The BALB/c allele affects the disease in an additive fashion with homozygosity conferring maximum susceptibility to autoimmune gastritis. Putative candidategenes in this region include the Tnfrsf1b, Tnfrsf8, Txgp1 and Tnfrsf9 genes.

References

• Original: J:54699 Silveira PA, et al., A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritis. J Immunol. 1999 May 1;162(9):5106-11
• All: 5 reference(s)