Start2^C57BL/6By
QTL Variant Detail

Summary

• QTL variant: Start2^C57BL/6By
• Name: startle response 2; C57BL/6By
• MGI ID: MGI:2155800
• QTL: Start2 Location: Chr4:124264957-124265153 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 57.76 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6By

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers earlier appearance of the startle response compared to NZB/BlNJ. (J:53794)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53794

Nineteen measures of sensorial, motor and body weight were subject to analysis in 389 female and male mice derived from reciprocal F1 and F2 mating of strains C57BL6/By and NZB/BlNJ . These traits were mapped via QTL analysis. In total 36 traits were mapped to chromosomes of which a number reached a threshold LOD score of 3.13 and were thus concidered significant. Two such QTL, startle response 1 (Start1) and startle response 2 (Start 2) mapped with mouse Chromosome 4 markers D4Mit205 ( LOD 3.87 ) and D4Mit12 (LOD 4.80) repectively. C57BL/6By-derived alleles confer earlier appearance of the startle response with a dominant mode of inheritance at Start1 and Start2.

References

• Original: J:53794 Le Roy I, et al., Preweanling sensorial and motor development in laboratory mice: quantitative trait loci mapping. Dev Psychobiol. 1999 Mar;34(2):139-58
• All: 1 reference(s)