Ccrs2^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Ccrs2^NZB/BlNJ
• Name: corpus callosum hemisphere surface size 2; NZB/BlNJ
• MGI ID: MGI:2155837
• QTL: Ccrs2 Location: Chr4:124264957-124265153 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 57.76 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased corpus callosum hemisphere surface size compared to C57BL/6By. (J:51052)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Significant interaction between Ccrs1 and Ccrs2 has been detected.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:51052

65 loci with an average spacing approximately of 25 cM were screened in 284 (C57BL/6By x NZB/B1NJ)F2 animals for linkage with corpus callosum hemisphere surface size. NZB/B1NJ has smaller corpus callosum hemisphere surface size compared to C57BL/6By. QTLs affecting corpus callosum hemisphere surface size, Ccrs1 and Ccrs2, were identified on mouse Chromosome 1 and mouse Chromosome 4, respectively. Ccrs1 maps to 81.6 cM - 106.3 cM on Chromosome 1 with a peak LOD score of 4.23 at D1Mit14. Ccrs2 maps to 57.6 cM - 78.5 cM on Chromosome 4 with a peak LOD score of 2.72 at D4Mit12. Two-way analyses showed significant interaction between Ccrs1 and Ccrs2.

References

• Original: J:51052 Roy IL, et al., Quantitative trait loci implicated in corpus callosum midsagittal area in mice. Brain Res. 1998 Nov 16;811(1-2):173-6
• All: 1 reference(s)