Bw7^DU6
QTL Variant Detail

Summary

• QTL variant: Bw7^DU6
• Name: body weight QTL 7; DU6
• MGI ID: MGI:2155853
• QTL: Bw7 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: DU6

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 4, Cyp4a10 (49.5 cM) shows differential expression between the restricted and unrestricted diets on a A/A^vy background while Tal1 (49.5 cM) shows differential expression between A/a and A/A^vy animals on the restricted diet. Diabesity QTLs Bw7 (59 cM) and Bwtq2 (55 cM) map near these candidate genes.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49578

F2-intercross pedigree analysis of progeny from crosses between a single male of the outbred mouse line DU6 (selected for high body weight) and a DUKs female (a randomly mated control line) was used to map quantitative trait loci (QTL). A QTL linked withbody weight, Bw7, was placed at 55cM on mouse Chromosome 4. A QTL associated with abdominal fat weight, Afw2, was placed at 51cM. A QTL associated with abdominal fat percent Afpq2 was placed at 55cM. A QTL associated with liver weight, Lwq1, was placed at 57cM.

References

• Original: J:49578 Brockmann GA, et al., Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth. Genetics. 1998 Sep;150(1):369-81
• All: 1 reference(s)