Nidd1^NON/LtHl
QTL Variant Detail

Summary

• QTL variant: Nidd1^NON/LtHl
• Name: non-insulin-dependent diabetes mellitus 1; NON/LtHl
• MGI ID: MGI:2155870
• QTL: Nidd1 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: NON/LtHl

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers diabetes susceptibility compared to NZO/Hl. (J:48957)
• Inheritance: Dominant

Notes

Candidate Genes

J:99477

Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes.

Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:48957

NON/LtHl inbred mice were selected for impaired glucose tolerance and NZO/Hl inbreds were selected for polygenic obesity, respectively. Their male F1 progeny consistently developed NIDDM (non-insulin-dependent diabetes mellitus).

A total of 193 (NZO/Hlx NON/LtHl)F2 and 201 (NON/LtHl x NZO/Hl)F2 mice were informative in identifying NIDDM susceptibility trait loci.

Nidd1 was contributed by the NON/LtHl background and mapped to an interval of mouse Chromosome 4 that contained the Lepr locus with a peak LOD of approximately 5.7.

References

• Original: J:48957 Leiter EH, et al., NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes. 1998 Aug;47(8):1287-95
• All: 1 reference(s)