Abcc1^tm1Bor
Targeted Allele Detail

Summary

• Symbol: Abcc1^tm1Bor
• Name: ATP-binding cassette, sub-family C member 1; targeted mutation 1, Piet Borst
• MGI ID: MGI:2155908
• Synonyms: mrp-, mrp1-, MRP1^-
• Gene: Abcc1 Location: Chr16:14179317-14292743 bp, + strand Genetic Position: Chr16, 9.75 cM
• Alliance: Abcc1^tm1Bor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44110
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin selection cassette replaced sequences encoding the first ATP binding domain. No full length or truncated protein was detected in western blots on extracts derived from a variety of tissues from homozygous mice. (J:44110)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc1 Mutation: 76 strains or lines available

References

• Original: J:44110 Wijnholds J, et al., Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med. 1997 Nov;3(11):1275-9
• All: 24 reference(s)