Tpnr1^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tpnr1^DBA/2J
• Name: thermal pain response 1; DBA/2J
• MGI ID: MGI:2155915
• QTL: Tpnr1 Location: Chr4:142230872-142230960 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 75.67 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased pain sensitivity in male animals compared to C57BL/6J.
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:40544

A mapping study was carried out to identify QTLs involved in pain response in the absence of analgesic. An initial screen was conducted on 24 BXD RI strains using over 1200 microsatellite markers. Candidate loci were subjected to secondary screening using 55 animals from a (C56BL/6J x DBA/2J)F2 intercross. C57BL/6J displays higher sensitivity to pain (i.e., lower hot plate (HP) latency), compared to DBA/2J. The C57BL/6J low HP latency phenotype is inherited in a dominant fashion as (C57BL/6J x DBA/2J)F1 animals exhibit HP latencies similar to C57BL/6J. QTL analysis identified 6 putative loci (data not shown), one of which maps to a candidate gene-rich region of chromosome 4 (50cM-80cM) in linkage with D4Mit13 (in F2 animals) and D4Ncvs63 (in RI strains).This locus, Tpnr1 (thermal pain response 1) appears to be sex-specific in its association with pain response in male animals. The authors investigated the possible role of a candidate gene in the mapped region of chromosome 4, Oprd1 (murine delta-opiod receptor), in pain response. Injection of animals with delta-opiod-specific agonsists affected HP latencies in a strain and sex-specific manner, which suggests Oprd1 may be the QTL, Tpnr1, involved in pain response.

References

• Original: J:40544 Mogil JS, et al., Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by delta2-opioid receptors. Pain. 1997 Apr;70(2-3):267-77
• All: 1 reference(s)