Abcc9^tm1Cfb
Targeted Allele Detail

Summary

• Symbol: Abcc9^tm1Cfb
• Name: ATP-binding cassette, sub-family C member 9; targeted mutation 1, Charles F Burant
• MGI ID: MGI:2155916
• Synonyms: Sur2 -
• Gene: Abcc9 Location: Chr6:142533588-142648041 bp, - strand Genetic Position: Chr6, 74.35 cM
• Alliance: Abcc9^tm1Cfb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71840
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Duplication, Insertion, Intragenic deletion
• Abcc9^tm1Cfb involves 1 genes/genome features (Abcc9) View all
• Mutation details: A neomycin selection cassette replaced sequences encoding the first ATP binding domain and a transmembrane domain. An additional integration event 3' to the gene caused a duplication of the gene between exons 9 to 27. Northern blot analysis indicated that no transcript was detectable from this allele in RNA derived from heart or skeletal muscle in homozygous mice. No protein activity was detected in cardiac myocytes or in skeletal muscle of homozygous mice. (J:71840)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc9 Mutation: 101 strains or lines available

References

• Original: J:71840 Chutkow WA, et al., Disruption of Sur2-containing KATP channels enhances insulin-stimulated glucose uptake in skeletal muscle. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11760-4
• All: 13 reference(s)