Tlsr2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Tlsr2^C57BL/6J
• Name: thymic lymphoma suppressor region 2; C57BL/6J
• MGI ID: MGI:2155941
• QTL: Tlsr2 Location: Chr4:124264957-142230960 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:31797

PCR analysis using microsatellite DNA polymorphic markers was preformed in (C57BL/6J x RF/J)F1 animals. Allelic losses were detected in 21/47 gamma-radiation induced thymic lymphomas. Analysis of markers located on six other chromosomes as well as on the proximal region of mouse Chromosome 4 indicated the existance of a tumor suppressor gene region (Tlsr1) on mouse Chromosome 4 of about 0.6 cM between the makers D4Wsm1 and D4Mit9. Additionally, a more distal tumor suppressor gene region (Tlsr2) was found centered at D4Mit54. From these data the following order of loci was determined on mouse Chromosome 4: D4Mit50, D4Mit17, D4Wsm1, Tlsr1, D4Mit9, D4Mit205, D4Mit12, Tlsr2, D4Mit54, D4Mit13.

References

• Original: J:31797 Santos J, et al., Allelic losses on chromosome 4 suggest the existence of a candidate tumor suppressor gene region of about 0.6 cM in gamma-radiation-induced mouse primary thymic lymphomas. Oncogene. 1996 Feb 1;12(3):669-76
• All: 1 reference(s)