Ace^tm3Unc
Targeted Allele Detail

Summary

• Symbol: Ace^tm3Unc
• Name: angiotensin I converting enzyme; targeted mutation 3, University of North Carolina
• MGI ID: MGI:2155951
• Synonyms: Tg(Acedup)2Unc, TgH(Acedup)2Unc
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm3Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42519
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A gap-repair type targeting vector was used to induce a gene duplication. Two tandem copies of the gene were present in the final allele. Protein activity measurments correlated with gene dosage in serum and lung tissue. (J:42519)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 57 strains or lines available

References

• Original: J:42519 Krege JH, et al., Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension. 1997 Jan;29(1 Pt 2):150-7
• All: 7 reference(s)