Ace^tm1Mcf
Targeted Allele Detail

Summary

• Symbol: Ace^tm1Mcf
• Name: angiotensin I converting enzyme; targeted mutation 1, Mark C Fishman
• MGI ID: MGI:2155955
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm1Mcf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32114
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Mutation details: The authors mutated the gene to eliminate expression from the somatic promoter of the gene while preserving expression from the testicular promoter. Specific construct details were not available. Homozygous mutant mice lack the protein in all tissues except the testes. (J:32114)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ace^tm1Mcf/Ace^tm1Mcf	Not Specified

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cardiovascular system	√
abnormal kidney vasculature morphology	√
growth/size/body	√
kidney medulla cyst	√
homeostasis/metabolism	√
increased blood urea nitrogen level	√
decreased urine osmolality	√
immune system	√
kidney inflammation	√
tubulointerstitial nephritis	√
mortality/aging	√
postnatal lethality, incomplete penetrance	√
renal/urinary system	√
abnormal kidney vasculature morphology	√
decreased urine osmolality	√
kidney inflammation	√
tubulointerstitial nephritis	√
abnormal kidney medullary ray morphology	√
dilated renal glomerular capsule	√
kidney cortex atrophy	√
abnormal kidney medulla morphology	√
kidney medulla cyst	√
abnormal kidney pelvis morphology	√
reproductive system	N
reproductive system phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 57 strains or lines available

Notes

The Ace^tm1Mcf mouse may serve as useful model system to study the progression of the nephronophthisis-uremic medullary cystic disease complex, a group of disorders that cause renal failure and are characterized by medullary cysts, corticotubular atrophy, interstitial inflammation, water wasting and uremia.

References

• Original: J:32114 Carpenter C, et al., Renal abnormalities in mutant mice [letter]. Nature. 1996 28;380(6572):292
• All: 1 reference(s)