Ace^tm1Mcf
Targeted Allele Detail

Summary

• Symbol: Ace^tm1Mcf
• Name: angiotensin I converting enzyme; targeted mutation 1, Mark C Fishman
• MGI ID: MGI:2155955
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm1Mcf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32114
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Mutation details: The authors mutated the gene to eliminate expression from the somatic promoter of the gene while preserving expression from the testicular promoter. Specific construct details were not available. Homozygous mutant mice lack the protein in all tissues except the testes. (J:32114)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 57 strains or lines available

Notes

The Ace^tm1Mcf mouse may serve as useful model system to study the progression of the nephronophthisis-uremic medullary cystic disease complex, a group of disorders that cause renal failure and are characterized by medullary cysts, corticotubular atrophy, interstitial inflammation, water wasting and uremia.

References

• Original: J:32114 Carpenter C, et al., Renal abnormalities in mutant mice [letter]. Nature. 1996 28;380(6572):292
• All: 1 reference(s)