Dob1^AKR/J
QTL Variant Detail

Summary

• QTL variant: Dob1^AKR/J
• Name: dietary obesity 1; AKR/J
• MGI ID: MGI:2155966
• QTL: Dob1 Location: Chr4:101574601-123127211 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: AKR/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased adiposity compared to SWR/J. (J:20129)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Candidate Genes

J:99477

Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes.

Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:20129

Analysis of F2 progeny from an intercross between AKR/J x SWR/J mice was done for Quantitative trait locus (QTL). Results of the analysis indicate that the locus for dietary obesity (Dob1) maps distal to db on Chromosome 4 with a LOD score of 4.4. The authors determined the order of loci in this region to be D4Mit5, db, Dob1, D4Mit11.

References

• Original: J:20129 West DB, et al., Genetics of dietary obesity in AKR/J x SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. Mamm Genome. 1994 Sep;5(9):546-52
• All: 1 reference(s)