Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Candidate Genes
Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Mapping and Phenotype information for this QTL, its variants and associated markersJ:20129Analysis of F2 progeny from an intercross between AKR/J x SWR/J mice was done for Quantitative trait locus (QTL). Results of the analysis indicate that the locus for dietary obesity (Dob1) maps distal to db on Chromosome 4 with a LOD score of 4.4. The authors determined the order of loci in this region to be D4Mit5, db, Dob1, D4Mit11. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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