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Dob1SWR/J
QTL Variant Detail
Summary
QTL variant: Dob1SWR/J
Name: dietary obesity 1; SWR/J
MGI ID: MGI:2155967
QTL: Dob1  Location: Chr4:101574601-123127211 bp  Genetic Position: Chr4, Syntenic
Variant
origin
Strain of Specimen:  SWR/J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased adiposity compared to AKR/J.
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Candidate Genes

J:99477

Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes.

Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:20129

Analysis of F2 progeny from an intercross between AKR/J x SWR/J mice was done for Quantitative trait locus (QTL). Results of the analysis indicate that the locus for dietary obesity (Dob1) maps distal to db on Chromosome 4 with a LOD score of 4.4. The authors determined the order of loci in this region to be D4Mit5, db, Dob1, D4Mit11.

References
Original:  J:20129 West DB, et al., Genetics of dietary obesity in AKR/J x SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. Mamm Genome. 1994 Sep;5(9):546-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory