Tlsr3^BALB/cJ
QTL Variant Detail

Summary

• QTL variant: Tlsr3^BALB/cJ
• Name: thymic lymphoma suppressor region 3; BALB/cJ
• MGI ID: MGI:2155973
• QTL: Tlsr3 Location: Chr4:129465811-136864536 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: BALB/cJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49558

Primary thymic lymphomas induced by gamma rays in (C57BL/6J x BALB/cJ)F1 mice and (BALB/cJ x C57BL/6J)F1 mice were examined for allelic loss using a number of mouse Chromosome 4 markers. The Tlsr2 tumor suppressor region mapping was centered at D4Mit205b.

10.20.2015_djr Curator Note: Because Tlsr2 was originally mapped in J:31797 in 1996 using

(C57BL/6J x RF/J)F1 mice, which differ from the population used here, we consider the current study a separate mapping experiment and have named this QTL Tlsr10.

A new critical region/quantitative trait locus involved in thymic lymphomagenesis, Tlsr3, was placed between D4Mit203 and D4Mit68.

References

• Original: J:49558 Santos J, et al., A new candidate site for a tumor suppressor gene involved in mouse thymic lymphomagenesis is located on the distal part of chromosome 4. Oncogene. 1998 Aug 20;17(7):925-9
• All: 1 reference(s)