Psen1^tm1Jzt
Targeted Allele Detail

Summary

• Symbol: Psen1^tm1Jzt
• Name: presenilin 1; targeted mutation 1, Joe Z Tsien
• MGI ID: MGI:2155978
• Synonyms: PS1 (f)
• Gene: Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
• Alliance: Psen1^tm1Jzt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73252
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette and a single loxP site were inserted 3' to exon 4, and a single loxP site was inserted 5' to exon 4. (J:73252)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psen1 Mutation: 48 strains or lines available

References

• Original: J:73252 Feng R, et al., Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron. 2001 Dec 6;32(5):911-26
• All: 23 reference(s)