Acvrl1^tm1Dyl
Targeted Allele Detail

Summary

• Symbol: Acvrl1^tm1Dyl
• Name: activin A receptor, type II-like 1; targeted mutation 1, Dean Y Li
• MGI ID: MGI:2155981
• Synonyms: Alk1^-
• Gene: Acvrl1 Location: Chr15:101026403-101043217 bp, + strand Genetic Position: Chr15, 56.41 cM, cytoband F3
• Alliance: Acvrl1^tm1Dyl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65521
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Mutation details: The mutation disrupted trancriptional and translational initiation. No specific molecular details were described. In situ hybridization experiments confirmed that expression of the transcript is undetectable in homozygous mice. (J:65521, J:85366)

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvrl1 Mutation: 27 strains or lines available

References

• Original: J:65521 Urness LD, et al., Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat Genet. 2000 Nov;26(3):328-31
• All: 4 reference(s)