Adora2a^tm1Jfc
Targeted Allele Detail

Summary

• Symbol: Adora2a^tm1Jfc
• Name: adenosine A2a receptor; targeted mutation 1, Jiang-Fan Chen
• MGI ID: MGI:2155985
• Synonyms: A2A, A2AAR^-, A2A KO, A2aR-, A2AR KO, Adora2a^tm1Chren, gKO
• Gene: Adora2a Location: Chr10:75152711-75170618 bp, + strand Genetic Position: Chr10, 38.52 cM, cytoband B5.3
• Alliance: Adora2a^tm1Jfc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73594
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 and intron 2 was replaced by a neomycin selection cassette. The absence of functional protein was demonstrated in homozygous mice by in situ binding assays and neurochemical tests. (J:73594)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adora2a Mutation: 40 strains or lines available

References

• Original: J:73594 Chen JF, et al., A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J Neurosci. 1999 Nov 1;19(21):9192-200
• All: 151 reference(s)