Hcs5^C3H/He
QTL Variant Detail

Summary

• QTL variant: Hcs5^C3H/He
• Name: hepatocarcinogenesis susceptibility 5; C3H/He
• MGI ID: MGI:2155988
• QTL: Hcs5 Location: unknown Genetic Position: Chr5, cM position of peak correlated region/allele: 44.78 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/He

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased hepatocarcinogenesis susceptibility compared to C57BL/6ByJ and M. spretus. (J:20738)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:20738

Quantitative trait locus analysis was used to find loci involved in hepatocarcinogenesis susceptibility in 106 male progeny from the (C3H/He x M. spretus)F1 x C57BL/6JBy backcross. One locus, Hcs5, maps to Chromosome 5 in the region of D5Mit6 with a peakLOD score of 2.27 and P < 0.0001.

References

• Original: J:20738 Manenti G, et al., Multiple loci affect genetic predisposition to hepatocarcinogenesis in mice. Genomics. 1994 Sep 1;23(1):118-24
• All: 1 reference(s)