Elmaz2^A/J
QTL Variant Detail

Summary

• QTL variant: Elmaz2^A/J
• Name: elevated maze behavior 2; A/J
• MGI ID: MGI:2155995
• QTL: Elmaz2 Location: Chr5:125178229-141700466 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 77.27 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers decreased preference for open arm entry and decreased number of open arm entries in the elevated maze test compared to CBA/J.
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:70379

A (A/J-Tyr^c/Tyr^c x CBA/J-Pdeb^rdl/Pdeb^rdl)F2 intercross was used to map QTLs associated with elevated plus maze behavior. Parental strain A/J-Tyr^c/Tyr^c is albino with a mutation in the tyrosinase gene and exhibits strong preference for closed arm entry of the maze. Parental strain CBA/J-Pdeb^rdl/Pdeb^rdl is mutant for the Pde6b gene and exhibits a weak preference for open arm entry of the maze. Two loci on mouse Chromosome 5, Elmaz1 and Elmaz2, are linked to open arm entry at 52 cM - 63 cM (LOD=1 6.4 between D5Mit20 and D5Mit405) and at 69 cM - 81 cM (LOD = 30.9 between D5Mit138 and D5Mit101), respectively. Pde6b maps to the first Chromosome 5 interval and is a strong candidate gene for Elmaz1. There is also evidence of linkage of closed armmaze entry with the Tyr gene on mouse Chromosome 7 at 44 cM.

References

• Original: J:70379 Cohen RM, et al., Quantitative trait loci affecting the behavior of A/J and CBA/J intercross mice in the elevated plus maze. Mamm Genome. 2001 Jul;12(7):501-7
• All: 1 reference(s)