Listr1^BALB/cByJ
QTL Variant Detail

Summary

• QTL variant: Listr1^BALB/cByJ
• Name: listeriosis resistance 1; BALB/cByJ
• MGI ID: MGI:2156006
• QTL: Listr1 Location: Chr5:77246081-77246203 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 41.45 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/cByJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers listeriosis resistance compared to C57BL/6ByJ. (J:68879)
• Inheritance: Not Specified

Notes

Animals homozygous for resistance alleles at both Listr1 and Listr2 exhibit the highest survival times.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68879

116 female (BALB/cByJ x C57BL/6ByJ)F2 animals were used to map QTLs associated with resistance to infection by Listeria monocytogenes. Animals were injected intravenously with 2-5 x 10⁴ CFU of L.monocytogenes and assessed for survival time. Death occurs in animals from BALB/cByJ parental strain within 72 hours of inoculation while animals from parental strain C57BL/6ByJ survive indefinitely. QTLs for listeriosis resistance, Listr1 and Listr2, mapped to mouse Chromosome 5 from 41 cM - 59 cM (LOD = 6.8 at D5Mit357) and mouse Chromosome 13 (LOD = 9.5 at D13Mit233), respectively. At Listr1, BALB/cByJ-derived alleles appear to increase survival time in (BALB/cByJ x C57BL/6ByJ)F2 animals infected with L.monocytogenes while the C57BL/6ByJ-derived allele increases survival time in a dominant fashion at Listr2. Animals homozygous for resistance alleles at both loci exhibited greatest survival time whereas animals homozygous for susceptibility alleles at both loci exhibited the shortest average survival time.

References

• Original: J:68879 Boyartchuk VL, et al., Multigenic control of Listeria monocytogenes susceptibility in mice. Nat Genet. 2001 Mar;27(3):259-60
• All: 1 reference(s)