Clgn^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Clgn^tm1Osb
• Name: calmegin; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:2156041
• Synonyms: calmegin-, Clgn^tm1Oka
• Gene: Clgn Location: Chr8:84116496-84155181 bp, + strand Genetic Position: Chr8, 39.97 cM
• Alliance: Clgn^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40831
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into the second exon disrupted the start codon. Northern blot analysis of testis did not detect transcript in homozygous mutant mice. Immunoblot analysis of testis did not detect protein in homozygous mutant mice. (J:40831)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clgn Mutation: 53 strains or lines available

References

• Original: J:40831 Ikawa M, et al., The putative chaperone calmegin is required for sperm fertility. Nature. 1997 Jun 5;387(6633):607-11
• All: 7 reference(s)